Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 153, Issue 1-2, Pages 171-182Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2004.05.007
Keywords
capsaicin; cytokines; mast cells; NGF; neuropeptides; neurogenic inflammation
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Intraplantar (i.pl.) injection of small doses of capsaicin has been shown to produce hyperalgesia and upregulation of the levels of proinflammatory cytokines. The present work aimed at investigating the possible mediation of these effects by sensory neuropeptides and mast cells. Various groups of rats received i.pl. injection of capsaicin alone or preceded by the injection of antagonists to substance P (SP), calcitonin gene-related protein (CGRP) and histamine (H-1, H-2) or the mast cell blocker ketotifen. All pretreatments prevented, in a dose-related manner, the capsaicin-induced hyperalgesia. The SP, H-2 antagonists and ketotifen prevented the upregulation of all cytokines and nerve growth factor (NGF) levels, while the CGRP and H-1 antagonists showed only attenuation of the NGF level. (C) 2004 Elsevier B.V. All rights reserved.
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