Journal
PHYTOTHERAPY RESEARCH
Volume 18, Issue 8, Pages 667-669Publisher
WILEY
DOI: 10.1002/ptr.1504
Keywords
Terminalia triflora-1; combretaceae; punicalim; 2-O-galloyl punicalin; HIV-1-RT inhibition
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The bioassay- guided fractionation of the aqueous extract of Terminalia triflora leaves afforded punicalin and 2-O-galloylpunicalin, isolated for the first time from this species. These compounds showed inhibitory activity on HIV-1 reverse transcriptase in a dose dependant manner. Punicalin showed an IC50 of 0.11 mug/ml (0.14 muM) and 2-O-galloylpunicalin an IC50 of 0.10 mug/ml (0.11 muM). Copyright (C) 2004 John Wiley Sons, Ltd.
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