Journal
DNA REPAIR
Volume 3, Issue 8-9, Pages 781-796Publisher
ELSEVIER
DOI: 10.1016/j.dnarep.2004.06.001
Keywords
cellular response; DNA double strand breaks; eukaryotic cells
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DNA double strand breaks (DSBs) are among the most dangerous lesions that can occur in the genome of eukaryotic cells. Proper repair of chromosomal DSBs is critical for maintaining cellular viability and genomic integrity and, in multi-cellular organisms, for suppression of tumorigenesis. Thus, eukaryotic cells have evolved specialized and redundant molecular mechanisms to sense, respond to, and repair DSBs. in this chapter, we provide an overview of the progress that has been made over the last decade in elucidating the identity and function of components that participate in the cellular response to chromosomal DSBs. Then, we discuss, in more depth, the response to DSBs that occur in the context of the V(D)J recombination and IgH class switch recombination reactions that occur in cells of the lymphocyte lineage. (C) 2004 Elsevier B.V. All rights reserved.
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