Journal
LUNG CANCER
Volume 45, Issue -, Pages S45-S48Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/j.lungcan.2004.04.025
Keywords
prognostic factor; angiogenesis; tumour necrosis; epidermal growth factor receptor expression; cyclooxygenase (COX)-2; matrix metalloproteinases
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In the UK mortality from malignant mesothelioma (MM) is likely to more than double over the next 20 years and despite advances in surgery, chemotherapy and radiation treatment the overall prognosis for patients remains poor. A number of scoring systems based on assessment of clinicopathological features of patients with the disease have been developed but the search continues for further prognostic indicators. Angiogenesis, tumour necrosis (TN), epidermal growth factor receptor (EGFR) expression, cyclooxygenase-2 (COX-2) and matrix metalloproteinases (MMPs) have been linked with poor prognosis in some types of solid tumour and their relevance as prognostic factors in malignant mesothelioma is examined in this paper. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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