Journal
DRUG RESISTANCE UPDATES
Volume 7, Issue 4-5, Pages 257-266Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.drup.2004.07.002
Keywords
Leishmania; leishmaniasis; kala azar; pentavalent antimonials; stibogluconate; Pentostam; meglumine antimoniate; Glucantime; pentamidine; amphotericin B; miltefosine; fluconazole; ABC transporters
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The control of Leishmania infections relies primarily on chemotherapy. The arsenal of drugs available for treating Leishmania infections is limited and includes pentavalent antimonials, pentamidine, amphotericin B, miltefosine, fluconazole and few other drugs at various stages of their development process. In this review, we will discuss the latest results regarding resistance mechanisms to drugs used in the clinic against Leishmania infections. (C) 2004 Elsevier Ltd. All rights reserved.
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