Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 7, Issue 4, Pages 369-374Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2004.05.001
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Antigenic variation allows African trypanosomes to develop chronic infections in mammalian hosts. This process results from the alternative occurrence of transcriptional switching and DNA recombination targeted to a telomeric locus that contains the gene of the variant antigen and is subjected to mono-allelic expression control. So far, the identification of mechanisms and factors involved still resists technological developments and genome sequencing.
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