Journal
JOURNAL OF NATURAL PRODUCTS
Volume 67, Issue 8, Pages 1252-1255Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np030198b
Keywords
-
Funding
- NCI NIH HHS [CA44344-05-12, R01 CA 90441-01] Funding Source: Medline
Ask authors/readers for more resources
The Gulf of California shell-less mollusc Dolabella auricularia has been found to contain a new 14-membered macrocyclic lactone linked to a 2,4-di-O-methyl-L-alpha-rhamnopyranoside, designated dolastatin 19 (1). The new cancer cell growth inhibitor (1, 8.33 x 10(-8)% yield) was obtained by bioassay (P388 lymphocytic leukemia and human cancer cell lines) directed isolation, accompanied by debromoaplysiatoxin (9.17 x 10(-7)% yield) and anhydrodebromoaplysiatoxin (2.0 x 10(-7)% yield). The structures were determined on the basis of analyses of high-resolution mass spectra and high-field NMR data. All the relative stereochemistry for the chiral centers was designated by utilizing NMR techniques.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available