Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 15, Issue 4, Pages 237-254Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2004.03.004
Keywords
PDGF; cardiovascular disease; smooth muscle cell; signaling; regulation
Categories
Funding
- NHLBI NIH HHS [HL18645] Funding Source: Medline
Ask authors/readers for more resources
Platelet-derived growth factor (PDGF) was identified in a search for serum factors that stimulate smooth muscle cell (SMC) proliferation. During the development of lesions of atherosclerosis that can ultimately lead to vessel occlusion, SMC are stimulated by inflammatory factors to migrate from their normal location in the media. They accumulate within the forming lesion where they contribute to lesion expansion by proliferation and deposition of extracellular matrix. Different genetic manipulations in vascular cells combined with various inhibitory strategies have provided strong evidence for PDGF playing a prominent role in the migration of SMC into the neointima following acute injury and in atherosclerosis. Other activities of PDGF identified in vivo suggest additional functions for PDGF in the pathogenesis of cardiovascular disease. (C) 2004 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available