Journal
MICROBES AND INFECTION
Volume 6, Issue 10, Pages 946-959Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2004.04.016
Keywords
toll-like receptors; mycobacterium tuberculosis infection; lipoarabinomannan; bacterial lipoproteins
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The control of Mycobacterium tuberculosis infection depends on recognition of the pathogen and the activation of both the innate and adaptive immune responses. Toll-like receptors (TLR) were shown to play a critical role in the recognition of several pathogens. Mycobacterial antigens recognise distinct TLR resulting in rapid activation of cells of the innate immune system. Recent evidence from in vitro and in vivo investigations, summarised in this review demonstrates TLR-dependent activation of innate immune response, while the induction of adaptive immunity to mycobacteria may be TLR independent. (C) 2004 Elsevier SAS. All rights reserved.
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