Journal
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
Volume 36, Issue 4, Pages 375-379Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/B:JOBB.0000041771.66775.d5
Keywords
MPTP; Parkinson's disease; neurodegeneration; mitochondria; oxidative stress; ATP depletion; programmed cell death
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Funding
- NIA NIH HHS [R01 AG021617-01] Funding Source: Medline
- NINDS NIH HHS [P01 NS11766-27A1, P50 NS38370, R01 NS38586, R29 NS37345, NS42269] Funding Source: Medline
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1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent neurotoxin extensively used to model Parkinson's disease (PD). A cascade of deleterous events, in which mitochondria play a pivotal role, drives MPTP neurotoxicity. How mitochondria are affected by MPTP and how their defect contributes to the demise of dopaminergic neurons in this model of PD are discussed in this review.
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