Journal
ANASTHESIOLOGIE INTENSIVMEDIZIN NOTFALLMEDIZIN SCHMERZTHERAPIE
Volume 39, Issue 8, Pages 456-462Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2004-825736
Keywords
xenon; neuroprotection; myocardial protection; reperfusion injury; preconditioning
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Besides it's anaesthetic properties, xenon may induce biological effects that may protect various organs from ischaemia-reperfusion injury. Xenon is an antagonist of the NMDA-receptor and reduces the neuronal injury mediated via these receptors. In contrast to other NMDA-receptor antagonists, xenon has no neurotoxic side effects. Xenon also protects the heart in ischaemia-reperfusion situations. Xenon reduces the post-ischaemic reperfusion injury and offers cardioprotection by inducing pharmacological preconditioning. These organprotective properties of xenon might be useful in special clinical situations.
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