Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 16, Issue 4, Pages 499-505Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2004.05.011
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Funding
- NIAID NIH HHS [R01AI054503] Funding Source: Medline
- NICHD NIH HHS [T32 HD07233-23] Funding Source: Medline
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The outcome of Mycobacterium infection is determined by a series of complex interactions between the bacteria and host immunity. Traditionally, mammalian models and cultured cells have been used to study these interactions. Recently, ameba (Dictyostelium), fruit flies (Drosophila) and zebrafish, amenable to forward genetic screens, have been developed as models for mycobacterial pathogenesis. Infection of these hosts with mycobacteria has allowed the dissection of intracellular trafficking pathways (Dictyostelium) and the roles of phagocytic versus antimicrobial peptide responses (Drosophila). Real-time visualization of the optically transparent zebrafish embryo/larva has elucidated mechanisms by which Mycobacterium-infected leukocytes migrate and subsequently aggregate into granulomas, the hallmark pathological structures of tuberculosis.
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