Journal
NEUROSCIENTIST
Volume 10, Issue 4, Pages 325-336Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858404263516
Keywords
N-methyl-D-aspartate (NMDA); ethanol; phosphorylation; RACK1; DARPP-32
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Funding
- NIAAA NIH HHS [R01 AA013438, R01AA/MH13438-O1A1] Funding Source: Medline
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One of the major targets for ethanol (alcohol) in the brain is the N-methyl-D-aspartate (NMDA) receptor, a glutamate-gated ion channel. Intriguingly, the effects of ethanol on the NMDA receptor are not homogeneous throughout the brain. This review focuses on recent studies revealing molecular mechanisms that mediate the actions of ethanol on the NMDA receptor in different brain regions via changes in NMDA receptor phosphorylation and compartmentalization. Specifically, the role of the scaffolding protein RACK1 and the regulatory protein DARPP-32 in mediating the distinct effects of ethanol is presented.
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