Journal
NEUROIMAGE
Volume 22, Issue 4, Pages 1704-1714Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2004.03.036
Keywords
famous faces; hippocampal region; medial temporal lobe
Funding
- MRC [G9439390, G0001237] Funding Source: UKRI
- Medical Research Council [G9439390, G0001237] Funding Source: Medline
- Wellcome Trust [064351] Funding Source: Medline
- Medical Research Council [G9439390, G0001237] Funding Source: researchfish
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There is currently a debate regarding the precise role of medial temporal regions in memory, in particular regarding the time scale of their involvement in conscious recollection of information stored in long-term memory. Using event-related fMRI, we have attempted to contribute to this debate by identifying brain regions associated with the successful recognition of famous faces from two different periods: Old faces of people who became famous in the 1960s-1970s and Recent faces of people who became famous in the 1990s. We demonstrate that the hippocampus is involved in the successful recognition of famous faces from both periods and does not appear to distinguish between these two periods. We also highlight a network of brain regions, including the left prefrontal cortex, the retrosplenial cortex, the temporo-parietal junction, the caudate and the right cerebellum, which is activated in association with successful recognition of famous faces. Finally, an analysis of the results obtained during a post hoc episodic recognition task shows the specific involvement of anterior hippocampus in the successful encoding of the unfamiliar faces, which were presented during the fame decision task, suggesting a functional distinction between anterior and posterior parts of the hippocampus, the former being specifically involved in successful episodic encoding and the latter being associated with successful retrieval of semantic information. (C) 2004 Elsevier Inc. All rights reserved.
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