Journal
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
Volume 36, Issue 4, Pages 381-386Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/B:JOBB.0000041772.74810.92
Keywords
mitochondria; oxidative damage; free radicals; Alzheimer's; Parkinson's; coenzyme Q(10)
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There is substantial evidence that mitochondrial dysfunction and oxidative damage may play a key role in the pathogenesis of neurodegenerative disease. Evidence supporting this in both Alzheimer's and Parkinson's diseases is continuing to accumulate. This review discusses the increasing evidence for a role of both mitochondrial dysfunction and oxidative damage in contributing to beta-amyloid deposition in Alzheimer's disease. I also discuss the increasing evidence that Parkinson's disease is associated with abnormalities in the electron transport gene as well as oxidative damage. Lastly, I reviewed the potential efficacy of coenzyme Q as well as a number of other antioxidants in the treatment of both Parkinson's and Alzheimer's diseases.
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