Journal
NEPHROLOGY DIALYSIS TRANSPLANTATION
Volume 19, Issue -, Pages 34-40Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfh1054
Keywords
cardiac failure; dialysis; drug therapy; microinflammation; oxidative stress; uraemia
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Microinflammation in renal failure has been the subject of numerous studies, but the causes of the inflammatory response in these patients are not clear. There are several potential causes and possible therapies for microinflammation, and they are discussed in this review with regard to uraemia and acidosis, heart failure and volume overload, oxidative stress and iron therapy, and bioincompatibility, especially regarding dialysis membranes. In addition, issues regarding dialysate contamination and access site infection are examined, followed by a discussion of possible drug therapy for microinflammation with angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists, statins, aspirin, and antioxidants, such as vitamin E.
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