Journal
JOURNAL OF NATURAL PRODUCTS
Volume 67, Issue 8, Pages 1392-1395Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np049975d
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Funding
- NCRR NIH HHS [P20 RR-16455-02] Funding Source: Medline
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Berkeley Pit Lake is a 1500 ft deep abandoned open-pit copper mine filled with 30 billion gallons of acidic, metal-contaminated water. This harsh environment is proving to be a source of unusual, biologically active microorganisms. Bioassay-guided fractionation using signal transduction enzyme assays led to the isolation of three novel bisabolane sesquiterpenes and a novel coumarin. The isolation and characterization of these compounds are reported here.
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