Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 16, Issue 4, Pages 456-462Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2004.05.002
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- Medical Research Council [G9800943] Funding Source: Medline
- Medical Research Council [G9800943] Funding Source: researchfish
- MRC [G9800943] Funding Source: UKRI
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Persistent viruses, such as herpesviruses, transmit infection by evading cytotoxic T cells during lytic replication. The gamma-herpesviruses additionally evade T cells during the proliferation of latently infected lymphocytes to establish a persistent viral reservoir. Lytic gene expression in sites of lymphoproliferation appears to make a vital contribution to this latent immune evasion. Lytic antigens may therefore be a key immune target. Investigations into a murine gamma-herpesvirus have now provided evidence that vaccination with apathogenic, latency-deficient mutants can largely protect against subsequent wild-type gamma-herpesvirus latency establishment.
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