Journal
NATURE REVIEWS CANCER
Volume 4, Issue 8, Pages 617-629Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc1413
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In mammals, the X chromosome is unique within the chromosome set. In contrast to the other chromosomes - for which two active copies are present - both male and female cells carry only one active X chromosome. This is because males have only one X chromosome and in females only one copy is active, a situation that leads to specific characteristics for genes located on this chromosome. How are the outcomes of genetic events involved in cancer - namely activation of oncogenes and inactivation of tumour suppressors - expected to be different when these genes are carried on the X chromosome rather than on autosomes?
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