Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 15, Issue 4, Pages 205-213Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2004.03.003
Keywords
PDGF signaling; growth factor; tissue culture; mouse models
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Since its discovery over three decades ago, platelet-derived growth factor (PDGF) has been a model system for learning how growth factors regulate biological processes. For the first several decades investigators used cells grown in tissue culture. More recently, PDGF signaling has also been investigated in mice. This review outlines the advances in these two systems, and highlights some of the directions for future investigation. (C) 2004 Elsevier Ltd. All rights reserved.
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