Journal
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
Volume 179, Issue 8, Pages 1595-1603Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10426500490464186
Keywords
anticancer activity; phosphorus oxychloride; triazolothiadiazoles
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3-Substituted-4-amino-5-mercapto-1,2,4-triazoles are versatile synthons for constructing various biologically active heterocycles. Their cyclization with, carboxylic acids gives fused five-membered derivatives, whereas with alpha-bromoketones gives a six-membered heterocycle. In. this article we report the synthesis of a series of 1,2,4-triazolo[3,4-b]thiadiazoles 5 starting from.4-amino-3-substituted-5-merccipto-1,2,4-triazoles 3 and fluorobenzoic acids 4 using phosphorous oxychloride as cyclizing agent. Fourteen. of the newly synthesized compounds were screened for anticancer properties. Four among their showed in vitro anticancer activity.
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