Journal
APPLIED SPECTROSCOPY
Volume 65, Issue 9, Pages 1004-1008Publisher
SOC APPLIED SPECTROSCOPY
DOI: 10.1366/11-06310
Keywords
Drugs of abuse; Saliva; Surface-enhanced Raman spectroscopy; SERS
Categories
Funding
- National Science Foundation [DMI-0215819]
- National Institutes of Health [1R43CA94457-01]
- UK Home Office Scientific Development Branch
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Eighty drugs of abuse and metabolites were successfully measured by surface-enhanced Raman spectroscopy (SERS) using gold- and silver-doped sol-gels immobilized in glass capillaries. A method was developed that provided consistent detection of 50 ppb cocaine in saliva in a focused study. This general method was successfully applied to the detection of a number of additional drugs in saliva, such as amphetamine, diazepam, and methadone.
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