Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 153, Issue 1-2, Pages 108-121Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2004.04.015
Keywords
relapsing-remitting EAE; FTY720; lymphopoenia; gene expression
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FTY720 is a prodrug for FTY-phosphate, an agonist at four of the five known receptors for sphingosine-1-phosphate (S1P). We show that administration of either FTY720 or FTY-P to SJL mice with established relapsing-remitting experimental autoimmune encephalitis (EAE) results in a rapid and sustained improvement in their clinical status, and a reversal of changes in expression of mRNAs encoding some myelin proteins and inflammatory mediators. EAE produced by adoptively transferring lymph node cells from immunized mice to naive hosts is similarly ameliorated by FTY-P. Treatment with FTY-P is accompanied by a dose-responsive peripheral lymphopoenia. (C) 2004 Elsevier B.V. All rights reserved.
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