Journal
DNA REPAIR
Volume 3, Issue 8-9, Pages 827-833Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2004.03.037
Keywords
homologous; recombination; DNA double-strand break; genome; prokaryotes; eukaryotes; Holliday junction
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Exchange of DNA strands between homologous DNA molecules via recombination ensures accurate genome duplication and preservation of genome integrity. Biochemical studies have provided insights into the molecular mechanisms by which homologous recombination proteins perform these essential tasks. More recent cell biological experiments are addressing the behavior of homologous recombination proteins in cells. The challenge ahead is to uncover the relationship between the individual biochemical activities of homologous recombination proteins and their coordinated action in the context of the living cell. (C) 2004 Elsevier B.V. All rights reserved.
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