Journal
APPLIED SPECTROSCOPY
Volume 64, Issue 9, Pages 980-985Publisher
SAGE PUBLICATIONS INC
DOI: 10.1366/000370210792434260
Keywords
Rare earth; Tb3+ ions; Schiff base; X-ray crystallography; Calf thymus DNA binding; Antioxidation; Ultraviolet visible spectroscopy; Fluorescence spectroscopy
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Funding
- National Natural Science Foundation of China [20975046]
- Gansu NSF [3ZS 041-A25-016]
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Tb(III) complexes were prepared from Tb(NO3)(3).6H(2)O and four Schiff-base ligands derived from 8-hydroxyquinoline-2-carboxaldehyde with aroylhydrazines. X-ray crystal and other structural analyses indicate that Tb(III) and every ligand can form a binuclear Tb(III) complex with 1:1 metal-to-ligand stoichiometry and nine-coordination at the Tb(III) center. Viscosity titration experiments and fluorescent and ultraviolet visible (UV-Vis) spectroscopy results indicate that all the Tb(III) complexes can bind to Calf thymus DNA through intercalation with the binding constants at the order of magnitude of 10(6)-10(7) M-1, and they may be used as potential anticancer drugs, but complexes containing active phenolic hydroxy groups may have stronger antitumor activities. Antioxidation results indicate that all the Tb(III) complexes have strong abilities of scavenging hydroxyl radicals and superoxide radicals, but complexes containing active phenolic hydroxy groups show stronger scavenging effects on hydroxyl radicals and complexes containing N-heteroaromatic substituent show stronger scavenging effects on superoxide radicals. However, Tb(III) emission with these systems is not observed, for these ligands rather are quenchers and unable to sensitize this metal ion.
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