Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 52, Issue 2, Pages 248-257Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.20143
Keywords
dynamic contrast enhanced MRI; gadodiamide; arterial input function; mouse; RIF-1 tumor; perfusion
Funding
- NCI NIH HHS [P01 CA56690, CA51935, CA83105] Funding Source: Medline
- NIBIB NIH HHS [R01 EB00422] Funding Source: Medline
- NINDS NIH HHS [R01 NS40801] Funding Source: Medline
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A noninvasive technique for simultaneous measurement of the arterial input function (AIF) for gadodiamide (Omniscan) and its uptake in tumor was demonstrated in mice. Implantation of a tumor at a suitable location enabled its visualization in a cardiac short axis image. Sets of gated, low-resolution saturation recovery images were acquired from each of five tumor-bearing mice following intravenous administration of a bolus of contrast agent (CA). The AIF was extracted from the signal intensity changes in left ventricular blood using literature values of the CA relaxivity and a precontrast T-1 map. The time-dependent (H2O)-H-1 relaxation rate constant (R-1 = 1/T-1) in the tumor was modeled using the BOLus Enhanced Relaxation Overview (BOLERO) method in two modes regarding the equilibrium transcytolemmal water exchange system: 1) constraining it exclusively to the fast exchange limit (FXL) (the conventional assumption), and 2) allowing its transient departure from FXL and access to the fast exchange regime (FXR), thus designated FXL/FXR. The FXL/FXR analysis yielded better fittings than the FXL-constrained analysis for data from the tumor rims, whereas the results based on the two modes were indistinguishable for data from the tumor cores. For the tumor rims, the values of K-trans (the rate constant for CA transfer from the vasculature to the interstitium) and v. (volume fraction of the tissue extracellular and extravascular space) returned from FXL/FXR analysis are consistently greater than those from the FXL-constrained analysis by a factor of 1.5 or more corresponding to a CA dose of 0.05 mmole/kg. (C) 2004 Wiley-Liss, Inc.
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