Journal
EMERGING INFECTIOUS DISEASES
Volume 10, Issue 8, Pages 1412-1419Publisher
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid1008.030917
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- NCI NIH HHS [P30 CA 21765] Funding Source: Medline
- NIAID NIH HHS [R01 AI 40918] Funding Source: Medline
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Streptococcus agalactiae (group B streptococcus [GBS]) causes invasive human infections and bovine mastitis. This study examined the genetic relationship between bovine and human serotype III GBS by using molecular techniques that classify human serotype III GBS into four distinct phylogenetic lineages. Bovine serotype III GBS were largely contained in two lineages, which are distinct from the two major lineages (restriction digest types III-2 and III-3) that infect human neonates. One of the bovine lineages closely resembles the human III-1 lineage, whose members occasionally cause human neonatal infections. The bovine strains in the other lineage characteristically have an initiation factor IF2 gene (infB) H allele and multilocus sequence types that are not found in human GBS strains. Evidence suggests that this H allele lineage is related to the human III-3 lineage. These results support the assertion that human and bovine GBS are largely unrelated and provide further insight into the genetic relation between human and bovine GBS.
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