Journal
NATURE REVIEWS GENETICS
Volume 5, Issue 8, Pages 618-U4Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg1407
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Funding
- Biotechnology and Biological Sciences Research Council [BBS/E/R/00000669] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/E/R/00000669] Funding Source: Medline
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Interactions among loci or between genes and environmental factors make a substantial contribution to variation in complex traits such as disease susceptibility. Nonetheless, many studies that attempt to identify the genetic basis of complex traits ignore the possibility that loci interact. We argue that epistasis should be accounted for in complex trait studies; we critically assess current study designs for detecting epistasis and discuss how these might be adapted for use in additional populations, including humans.
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