Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 153, Issue 1-2, Pages 150-157Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2004.05.004
Keywords
CXCR3; blood-brain barrier; multiple sclerosis
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Funding
- NIMH NIH HHS [R01 MH063850] Funding Source: Medline
- NINDS NIH HHS [P01 NS38667] Funding Source: Medline
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Chemokines and their receptors may be implicated in leukocyte ingress into brain during inflammation observed during the course of multiple sclerosis (MS). To address receptor modulation on CD4+ memory T lymphocytes during diapedesis, we used an in vitro model of the blood-brain barrier (BBB). We found that only memory (CD45RO+) cells transmigrated and type 3 CXC chemokine receptor (CXCR3) was enriched on transmigrated cells. CXCR3 depletion of the input population did not affect transmigration capability. CXCR3 reemerged on CXCR3 depleted cells independently of endothelial cell exposure, but was susceptible to incubation at 4degreesC, indicating receptor recycling. We propose that CXCR3 serves as a surface marker for cells that have the capacity to cross the BBB, but does not play an essential role in extravasation. (C) 2004 Elsevier B.V. All rights reserved.
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