Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 14, Issue 15, Pages 4093-4097Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.05.016
Keywords
coumarins; sulfonamides; Jun kinase
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Synthesis of coumarin 3-(N-aryl) sulfonamides was accomplished either by Knoevenagel condensation of anilmosulfonylacetic acids with suitable salicylaidehydes or by the reaction of methyl anilmosulfonylacetates with substituted salicylaldehydes in presence of a catalytic amount of a base. All the compounds tested for antiproliferative activity in different cancer cell lines have shown GI(50) values less than 100 muM. (C) 2004 Elsevier Ltd. All rights reserved.
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