Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 496, Issue 1-3, Pages 213-214Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2004.06.022
Keywords
GLUT1 (glucose transporter1); endothelium; antisense
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Funding
- NHLBI NIH HHS [HL65667, T32 HL07853, HL60156] Funding Source: Medline
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We tested the hypothesis that decreased glucose transporter 1 (GLUT1) expression alters endothelial function. Nitric oxide-dependent endothelial relaxation, but not endothelium-independent relaxation, was significantly reduced in aortas from transgenic mice expressing GLUT1 antisense mRNA, compared to aortas from nontransgenic littermates. These data suggest that GLUT1-dependent glucose metabolism may play an important role in regulating endothelial function. (C) 2004 Elsevier B.V. All rights reserved.
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