Journal
JOURNAL OF CELL BIOLOGY
Volume 166, Issue 3, Pages 419-431Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200312074
Keywords
keratinocyte; apoptosis; differentiation; Akt; extracellular matrix
Categories
Ask authors/readers for more resources
Stratified squamous epithelia express the alphavbeta5 integrin, but in squamous cell carcinomas (SCCs) there is down-regulation of alphavbeta5 and up-regulation of alphavbeta6. To investigate the significance of this finding, we transduced an alphav-negative human SCC line with retroviral vectors encoding alphav integrins. alphavbeta5-expressing cells underwent suspension-induced apoptosis (anoikis), whereas alpha-negative cells and cells expressing alphavbeta6 did not. Resistance to anoikis correlated with PKB/Akt activation in suspension, but not with changes in PTEN or p110alpha P13 kinase levels.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available