Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable β-amyloid deposition

Environmental enrichment (EE) has been shown to improve cognitive performance and brain indices of cognition in normal mice an( rats. Because the therapeutic potential of intensive, long-term EF to benefit patients with Alzheimer's disease (AD) has yet to be explored, the present study evaluated the effect of long-term EE or cognition in an animal mode) of AD, the APPsw transgenic mouse Beginning at 16 months of age, APPsw mice were put into EE or standard housing for 4 months and then tested in four cognitive. based tasks (Morris maze, circular platform, platform recognition and radial arm water maze) between 20 and 22 months of age. Our results indicate that long-term EE of aged APPsw mice results in global, overall improvement in cognitive function across these tasks without decreasing brain beta-amyloid (Abeta) deposition. The results suggest that long-term EE/cognitive stimulation could provide cognitive stabilization or improvement to AD patients through mechanisms independent of Abeta deposition and clearance.