Journal
TETRAHEDRON-ASYMMETRY
Volume 15, Issue 15, Pages 2431-2436Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2004.06.002
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Polymeric chiral reductants selective for the reduction of (-)-menthone 1 to the diastereomeric products (-)-menthol 2 and (+)-neomenthol 3 were prepared by a covalent molecular imprinting using 2 as the template. The LiAlH4 derivatized imprinted polymers altered the natural outcome of the reduction reaction (LiAlH4) from 2:1 [(-)-menthol:(+)-neomenthol] to 1:1. The reaction mechanism is discussed in terms of reaction site structure. The molecularly imprinted polymers demonstrated enantioselective recognition for 2 (0.15 mumol enantioselective sites/g polymer) in batch binding experiments. (C) 2004 Elsevier Ltd. All rights reserved.
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