Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 47, Issue 17, Pages 4163-4165Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm034182u
Keywords
-
Categories
Ask authors/readers for more resources
The evaluation of a sulfonamide inhibitor of the p53-mdm2 interaction is presented. The compound was identified using 3D database searching techniques based on a computationally derived pharmacophore model of mdm2 binding. It inhibits the physical interaction of recombinant p53 and mdm2 in vitro and increases p53-dependent transcription in an mdm2-overexpressing cell line.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available