Journal
VACCINE
Volume 22, Issue 23-24, Pages 3087-3091Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2004.02.003
Keywords
pneumococcal vaccine; influenza vaccine; simultaneous vaccination; adverse reactions
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We studied adverse reactions to immunisation in 541 individuals receiving simultaneous pneumoccocal and influenza vaccination, and in 320 recipients of pneumococcal vaccine alone. Five days after immunisation, the participants completed a questionnaire covering systemic and local reactions to vaccination. Adverse effects were rated as mild if they did not interfere with the participant's daily activities, and moderate or serious if they moderately or markedly restricted these activities. There were no differences between the groups regarding general malaise, headache, myalgias and elevated body temperature. Redness at the injection site, but not soreness or swelling, occurred more frequently in individuals immunised simultaneously with both vaccines. Except for fever and local,welling, adverse reactions were significantly more frequent in women than in men in study groups. The rate of adverse reactions was higher in individuals less then 65 years of age than in older participants. Local reactions were reported by 358 (41.6%) participants, but they were mild and soon subsided. No serious reactions were reported. pneumococcal and influenza vaccine can be safely administered simultaneously. (C) 2004 Elsevier Ltd. All rights reserved.
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