Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 279, Issue 33, Pages 34087-34090Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.C400236200
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Funding
- NCI NIH HHS [CA 90917, CA 78810] Funding Source: Medline
- NHLBI NIH HHS [HL 54131] Funding Source: Medline
- NIA NIH HHS [AG 15393] Funding Source: Medline
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Regulators of apoptosis are thought to work in concert, but the molecular interactions of this process are not understood. Here, we show that in response to cell death stimulation, survivin, a member of the inhibitor of apoptosis (IAP) gene family, associates with another IAP protein, XIAP, via conserved baculovirus IAP repeats. Formation of a survivin-XIAP complex promotes increased XIAP stability against ubiquitination/proteasomal destruction and synergistic inhibition of apoptosis, which is abolished in XIAP(-/-) cells. Therefore, orchestration of an IAP-IAP complex regulates apoptosis.
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