Journal
CLINICAL CANCER RESEARCH
Volume 10, Issue 16, Pages 5566-5571Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-04-0076
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BNIP3 is a proapoptotic protein regulated by hypoxia-inducible factor 1. We analyzed BNIP3 expression in 105 tumor samples from early operable, non-small lung cancer and the relationship of expression to hypoxia-inducible factor 1(x, other hypoxia-regulated pathways, and prognosis. There was strong cytoplasmic expression in > 10 % of cells in 40 of 105 cases. BNIP3 expression was associated significantly with high hypoxia-inducible factor 1(x (P = 0.003), carbonic anhydrase 9 (P = 0.04), and was inversely associated with bcl-2 expression (P = 0.009). High BNIP3 expression was a major independent factor for overall survival. Thus, high expression of a hypoxia regulated proapoptotic pathway was associated with a selection of an aggressive phenotype in vivo.
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