Journal
JOURNAL OF CELL SCIENCE
Volume 117, Issue 18, Pages 4055-4066Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.01275
Keywords
protein folding; chaperones; organelle; signaling; genetics
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Funding
- NIDDK NIH HHS [DK47119] Funding Source: Medline
- NIEHS NIH HHS [ES08681] Funding Source: Medline
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Protein folding in the mitochondria is assisted by nuclear-encoded compartment-specific chaperones but regulation of the expression of their encoding genes is poorly understood. We found that the mitochondrial matrix HSP70 and HSP60 chaperones, encoded by the Caenorhabditis elegans hsp-6 and hsp-60 genes, were selectively activated by perturbations that impair assembly of multi-subunit mitochondrial complexes or by RNAi of genes encoding mitochondrial. chaperones or proteases, which lead to defective protein folding and processing in the organelle. hsp-6 and hsp-60 induction was specific to perturbed mitochondrial protein handling, as neither heat-shock nor endoplasmic reticulum stress nor manipulations that impair mitochondrial steps in intermediary metabolism or ATP synthesis activated the mitochondrial chaperone genes. These observations support the existence of a mitochondrial unfolded protein response that couples mitochondrial chaperone gene expression to changes in the protein handling environment in the organelle.
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