Journal
CARDIOVASCULAR RESEARCH
Volume 63, Issue 3, Pages 403-413Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.cardiores.2004.02.003
Keywords
hypertrophy; Ras; MAP kinase; P13-kinase; protein synthesis; mTOR; mRNA translation
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Cardiac hypertrophy involves increased mass (growth) of the heart and a cardinal feature of this condition is increased rates of protein synthesis. Several signaling pathways have been implicated in cardiac hypertrophy including the phosphatidylinositol 3-kinase (PI3K) and Ras/Raf/MEK/Erk pathways. PI3K lies upstream of the mammalian target of rapamycin (mTOR), an important positive regulator of protein synthesis and cell growth. However, recent data suggest that, in response to certain hypertrophic agents, signaling via Ras and MEK/Erk, as well as mTOR, is required for activation of protein synthesis, indicating new connections between these key signaling pathways. (C) 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
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