Journal
EMBO JOURNAL
Volume 23, Issue 16, Pages 3249-3258Publisher
WILEY
DOI: 10.1038/sj.emboj.7600329
Keywords
Frizzled 7; paraxial protocadherin; planar cell polarity; tissue separation; Xenopus laevis
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Protocadherins have homophilic adhesion properties and mediate selective cell-cell adhesion and cell sorting. Knockdown of paraxial protocadherin (PAPC) function in the Xenopus embryo impairs tissue separation, a process that regulates separation of cells of ectodermal and mesodermal origin during gastrulation. We show that PAPC can modulate the activity of the Rho GTPase and c-jun N-terminal kinase, two regulators of the cytoskeletal architecture and effectors of the planar cell polarity pathway. This novel signaling function of PAPC is essential for the regulation of tissue separation. In addition, PAPC can interact with the Xenopus Frizzled 7 receptor, and both proteins contribute to the development of separation behavior by activating Rho and protein kinase Calpha.
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