Journal
SYNTHESIS-STUTTGART
Volume -, Issue 12, Pages 2026-2034Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2004-829174
Keywords
N-2-acetyl-7-and 9-benzylguanine; benzylation; alkylations; hydrogenations; regioselectivity
Categories
Ask authors/readers for more resources
Reaction of N2-acetyl-9- and/or -7-benzylated guanines 8 and 12 with selected alkylating agents in 1-methyl-2-pyrrolidone at 120 degreesC yielded the guaninium salts 9 and 13. The salts were consequently transformed by phase transfer hydrogenation into N-7- and N-9-isomers 10 and 14, respectively, in a highly regioselective manner. A convenient deoxygenation of both derivatives, achieved via the corresponding O-6-arenesulfonates, into 2-aminopurine potential prodrugs was also established.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available