Medical diagnosis of cardiovascular diseases using an interval-valued fuzzy rule-based classification system

Objective: To develop a classifier that tackles the problem of determining the risk of a patient of suffering from a cardiovascular disease within the next 10 years. The system has to provide both a diagnosis and an interpretable model explaining the decision. In this way, doctors are able to analyse the usefulness of the information given by the system. Methods: Linguistic fuzzy rule-based classification systems are used, since they provide a good classification rate and a highly interpretable model. More specifically, a new methodology to combine fuzzy rule-based classification systems with interval-valued fuzzy sets is proposed, which is composed of three steps: (1) the modelling of the linguistic labels of the classifier using interval-valued fuzzy sets; (2) the use of the K-alpha operator in the inference process and (3) the application of a genetic tuning to find the best ignorance degree that each interval-valued fuzzy set represents as well as the best value for the parameter alpha of the K-alpha operator in each rule. Results: The suitability of the new proposal to deal with this medical diagnosis classification problem is shown by comparing its performance with respect to the one provided by two classical fuzzy classifiers and a previous interval-valued fuzzy rule-based classification system. The performance of the new method is statistically better than the ones obtained with the methods considered in the comparison. The new proposal enhances both the total number of correctly diagnosed patients, around 3% with respect the classical fuzzy classifiers and around 1% vs. the previous interval-valued fuzzy classifier, and the classifier ability to correctly differentiate patients of the different risk categories. Conclusion: The proposed methodology is a suitable tool to face the medical diagnosis of cardiovascular diseases, since it obtains a good classification rate and it also provides an interpretable model that can be easily understood by the doctors. (C) 2013 Elsevier B.V. All rights reserved.