Journal
INORGANIC CHEMISTRY
Volume 43, Issue 17, Pages 5373-5381Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ic0498586
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Funding
- NCI NIH HHS [T32-CA09634] Funding Source: Medline
- NIGMS NIH HHS [GM56279] Funding Source: Medline
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An octahedral rhodium complex (cis-dichloro(dipyrido[3,2a-2',3'c]phenazine)(1,10-phenanthroline)rhodium(ill) chloride; DPPZPHEN) has been prepared that can penetrate tumor cell membranes and the Sindbis viral capsid. The compound is phototoxic to these entities when irradiated with UVA light. Model studies with calf thymus and supercoiled plasmid DNA indicate that the complex can both bind with, and nick, nucleic acid. Analysis of Sindbis virus, following irradiation with the metal complex, confirmed that the viral genome was rendered noninfectious by this treatment.
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