Journal
TETRAHEDRON LETTERS
Volume 45, Issue 35, Pages 6591-6594Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.07.036
Keywords
alkyne; 1,4-addition; rhodium
Categories
Ask authors/readers for more resources
The metal complex Rh(acac)(CO)(2) in the presence of an eqimolar amount of tris(o-methoxyphenyl)phosphine provides a useful catalyst system for the 1,4-addition of alkynes to unsubstituted vinyl ketones. Best yields are obtained when the transformation is performed in benzene at reflux with an excess of vinyl ketone. Both aryl and alkyl substituted alkynes participate in the reaction. Primary alcohols and alkyl chlorides are well tolerated under these reaction conditions. The reaction also proceeds in aqueous solvent mixtures, unlike most organometallic addition reactions. (C) 2004 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available