Journal
OPTICS EXPRESS
Volume 12, Issue 17, Pages 3996-4000Publisher
OPTICAL SOC AMER
DOI: 10.1364/OPEX.12.003996
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A model-based image reconstruction method, bioluminescence tomography (BLT), is described. BLT has the potential to spatially resolve bioluminescence associated with gene expression in vivo, thus, offering a tomographic molecular imaging method. The three-dimensional spatial map of reporter genes is recovered using a diffusion equation model-based, finite element reconstruction algorithm. The imaging method is demonstrated using both numerical simulations and phantom experiments. (C) 2004 Optical Society of America.
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