Journal
JOURNAL OF NEUROSCIENCE
Volume 24, Issue 34, Pages 7576-7582Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2245-04.2004
Keywords
cone; rod; horizontal cell; retina; synapse; bipolar cell
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Funding
- NEI NIH HHS [R01 EY011115, EY11115, R01 EY012654, EY12654] Funding Source: Medline
- Telethon [E.0833] Funding Source: Medline
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In mammalian retinas, rods and cones connect to distinct sets of bipolar cells. In the retina of Nrl ( neural retina leucine zipper) knock-out mice, in which rods fail to form and all photoreceptors are cones, rod bipolar cells have normal morphology, pattern of staining, and lamination, but they form synaptic connections with cones. Hence, retinal interneurons are not entirely committed to the choice of their synaptic partners; also, their morphology and pattern of distribution of their processes in the synaptic layers of the retina are not instructed by the establishment of synaptic connections with cognate photoreceptor(s). These findings are of considerable relevance for our understanding of mechanisms responsible for cell recognition during development and in the context of using transplanted tissue to restore vision in retinal degeneration.
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