Journal
NEUROREPORT
Volume 15, Issue 12, Pages 1857-1860Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200408260-00004
Keywords
activity; DAMGO; feeding; food reward; muscimol; nucleus accumbens; palatability
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Funding
- NIDA NIH HHS [DA09311, F32 DA14751] Funding Source: Medline
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Endogenous opioid peptides within the nucleus accumbens are thought to mediate the hedonic aspects of food intake, particularly foods such as fat and sugar. In view of evidence that the amygdala also regulates positive affect, we hypothesized this brain region participates in the control of opioid-mediated food intake. The robust increase in the intake of fat following intra-accumbens administration of the p-opioid agonist D-Ala2,Nme-Phe4,Glyol5-enkephalin (DAMGO) was completely blocked by concurrent temporary inactivation (muscimol, GABA(A) agonist) of either the basolateral or central nucleus of the amygdala. In summary, we demonstrate that amygdala inactivation prevents the intra-accumbens opioid induced binge eating of fat, possibly through reducing the hedonic properties of high-fat palatable food.
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