Journal
JOURNAL OF BIOTECHNOLOGY
Volume 112, Issue 1-2, Pages 5-12Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jbiotec.2004.04.029
Keywords
single molecule force spectroscopy; atomic force microscopy; optical tweezers; ligand-DNA interaction
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Recent developments in single molecule force spectroscopy (SMFS) allow direct observation and measurements of forces that hold protein-DNA complexes together. Furthermore, the mechanics of double-stranded (ds) DNA molecules in the presence of small binding ligands can be detected. The results elucidate molecular binding mechanisms and open the way for ultra sensitive and powerful biosensor applications. (C) 2004 Elsevier B.V. All rights reserved.
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