Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1047, Issue 2, Pages 305-311Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2004.07.005
Keywords
fluoroquinolones; quinolones; antibiotics
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A capillary electrophoretic method has been developed for the separation of nine (fluoro)quinolones. Detection is done by fluorescence measurement with broad wavelength band excitation between 240 and 400 nm. Best separation is achieved in a carrier electrolyte containing 50 mM H3PO4 adjusted to pH 7.55-acetonitrile (60:40, v/v). Detection limits are in the low mug l(-1) range. The suitability to real samples has been demonstrated by analyzing blood samples and surface water samples. Sample preconcentration and sample clean-up can easily be done by solid-phase extraction. Different phases based on alkyl- or phenyl-modified silica as well as on polymers have been investigated for this purpose. The method should also be useful for determination of residues of (fluoro)quinolones in food or other matrices. (C) 2004 Elsevier B.V. All rights reserved.
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